Lipidomics Applications
Lipidomics fuels research and progress in biotech and pharma, food industry, cosmetics and dermatology, as well as academic research.
Biotech & Pharma
Lipids are ubiquitous to almost every biological process which make them prime targets for drug development and clinical diagnostics. Cardiovascular diseases, Alzheimer’s, diabetes, and cancer – many major diseases are already known to involve lipids.
Applications
- Biomarker & drug discovery (mode-of-action, target validation & more)
- Clinical screenings and diagnostics
- GMP compliant analysis (assay development, quality control & more)
Our Lipotype shotgun-technology platform combines more than 10 years of experience in sample preparation, MS analysis and bioinformatics to deliver absolute quantification of the hundreds of lipid species that are present in body fluids and cells. This can be achieved with an unprecedented throughput of thousands of samples at an affordable price.
The introduction of multi-parametric lipidomic data is bound to revolutionize clinical diagnostics, providing an accurate read-out for the health and disease status of an individual. Join the lipid revolution!
Further information
Lipotype is GMP certified!
Download the press release for more information about GMP certified lipidomics services
Patented – A Drug Discovery Case Study
Get the PDF to read the success story of a happy Lipotype customer
Lipid Analysis Services
Find out more about Lipotype Shotgun Lipidomics technology
Food Industry
These nasty fats, in science we call them ‘lipids’, are essential components of our diet, providing energy, helping to absorb vitamins and being the only source of essential fatty acids. However, imbalances and molecular quality of fats in our diet have profound effects on our health and well-being.
Applications
- Intervention studies for diet interventions
- Development of functional food and nutraceuticals
- Lipid composition analysis of ingredients
Studying lipids was up to know a non-trivial task, as lipidomics methods lacked essential features such as high-throughput and coverage for conducting population-wide studies. But the situation has changed with Shotgun Lipidomics, the first method that combines global lipid coverage and unprecedented high-throughput with absolute quantification of the lipid molecules.
Today, we can directly assess the influence of food, its additives and ingredients, as well as formulations on lipid composition and metabolism of the human body, without limitations in sample number or type. For example: it is now possible to address the problem of how differently saturated fatty acids influence the human lipidome!
Further information
Publication: How Diets Influence Your Lipidome
Study the free publication of Charité, DIfE and Lipotype
Yeast Lipids – A Food Development Case Study
Get the PDF to read about a functional food project
Lipid Analysis Services
Find out more about Lipotype Shotgun Lipidomics technology
Cosmetics & Dermatology
Skin. Its condition not only affects our health but also how we feel and look, making it the primary target for cosmetics. Skin lipid composition is influenced by natural conditions, such as age and gender, but altered lipid profiles have been also linked to diseases like atopic dermatitis or ichtyosis.
Applications
- Cosmetics claim support
- Topical drug development and validation
- Personalized cosmetics
Skin functionality and physiology derive from the structure and composition of its topmost layer, the stratum corneum, where brick-like corneocytes are sealed together with the natural mortar – lipids. These lipids, including mainly a dozen of different ceramide classes, cholesterol and its esters as well as triglycerides, render skin tight, impermeable and elastic.
The analysis of skin lipids has to fulfill two conditions. First, it needs to have broad coverage to encompass the variety of skin lipids and a throughput allowing statistically relevant studies. Second, it should be compatible with the most convenient sampling method: tape stripping. These prerequisites are exactly met with Lipotype Shotgun Skin Lipidomics!
Further information
Whitepaper: Skin Lipidomics
Download “Skin Lipidomics” for your studies
Balms – A Penetration Depth Case Study
Get the PDF to read the research story of a Lipotype customer
Lipid Analysis Services
Find out more about Lipotype Shotgun Lipidomics technology
Academic Research
Lipidomics remained for long in the background but is now moving center stage. The change has come with Shotgun Lipidomics, a method that combines global coverage and high-throughput with absolute quantification of thousands of lipid species that are encountered in cells and body fluids.
Applications
- Lipid analysis of various model organisms
- Organelles, bacteria, yeast, cultured cells, tissues and more
- A plethora of experimental setups
Most lipids reside in cell membranes forming the functional fluid matrix, where they are directly involved in intracellular trafficking, regulating membrane proteins, cellular architecture and membrane sub-compartmentalization. Each of these broadly defined roles constitutes an exciting target area of lipidomics.
The shotgun approach enables analysis of the collective role of lipids in membranes. Absolute quantification on the other hand makes it possible to track metabolic processes in detail. With Lipotype Shotgun Lipidomics technology it is possible to quantitatively assess the lipid composition to support cell and system biology research.
Further information
Publication: Omega-3 Fatty Acids Direct Differentiation
Study the free publication of UTH and Lipotype
Yale – A Research Collaboration Case Study
Get the PDF to read about our story with Pietro De Camilli
Lipid Analysis Services
Find out more about Lipotype Shotgun Lipidomics technology
Customers
Research what our customers say about us and learn why they prefer Lipotype Shotgun Lipidomics services.