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Cerebrosides

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Details

Sphingolipids
Lipid Category
Cerebrosides
Lipid Group

About the structure and biological function of Cerebrosides

Structure. Cerebrosides belong to the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral/non-acidic monosaccharide “head” group, such as galactose or glucose. The ceramide backbone of cerebrosides contains a hydrocarbon chain termed long-chain base; one fatty acid is linked to the ceramide.

Function. Cerebrosides are present in bacteria and eukaryotes such as animals, plants, and fungi. Many cerebrosides serve as precursors to diglycosylceramides and thus also to glycosphingolipids with more than two sugars in the head group (e.g. globosides, gangliosides, and sulfoglycosphingolipids). Apart from their biosynthetic role, they serve important biological functions.

Galactosylceramides are among the most researched cerebrosides and essential to myelin, the insulating layer that wraps around nerves. Glucosylceramides are an important constituent of the skin to maintain trans-epidermal water loss and may support the cell membrane of plants to overcome cold and drought stress. Little is known about cerebrosides with more exotic sugar molecules.

Research articles

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Cerebrosides lipidomics analysis with Lipotype

Covered classes 3
Approach untargeted/targeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
or
Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 2-6 weeks
Lipidomics data pmol & mol%

CORE STRUCTURE
Cerebrosides

General molecular structure of the lipid group cerebrosides.

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Lipid Navigator

Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Esters Fatty Amides Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA LiFA SCFA MCFA LCFA SFA UFA WE CAR NAE oxiOME oxiODE Pgd LT TX LX IsoP oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE Erg EE Sqe oxiSqe UQ

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