Dihydroceramide

We provide MS-based lipid analysis of dhCer sphingolipids in a variety of sample types and deliver results in six or less weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group
Dihydroceramide
Lipid Class

About the structure and biological function of dhCer

Structure. Dihydroceramides (N-acyl-sphinganines, or dhCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. In animals, dihydroceramides are primarily synthesized in the endoplasmic reticulum, and may then serve as biosynthetic precursor to ceramides. In comparison to ceramides, the absence of the double bond in the sphingoid base of dihydroceramides affects the biophysical properties of membranes rich in dhCer. They are linked to the production of reactive oxygen species in mitochondria, inducing and rectifying apoptosis, and accumulation of dhCer in the nervous system can lead to neuronal dysfunction.

Dihydroceramide lipidomics analysis with Lipotype

Structural details molecular species
Variants identified > 10
Approach targeted
Method mass spectrometry
Device Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 6 weeks
Lipidomics data pmol & mol%
Figuresyes

Example Structure
dhCer

An example for the molecular structure of dihydroceramide, specifically Cer(d18:0/20:0).

Lipid Navigator


ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

  • Thank you once again. The timing is extremely helpful to us.

    Susan Macdonald

    Aldeyra Therapeutics
  • Thank you very much. The results look fantastic!

    Stan Neufeld

    Friedrich Miescher Institute
  • The high-speed turn around when under revision really helped us!

    Rose E Goodchild

    KU Leuven
  • We highly appreciate the personal support and consultation.

    Rainer Voegeli

    DSM Skin Biology
  • We have been quite impressed. The results clearly indicate a difference.

    Pietro De Camilli

    Yale University
  • Cooperating with Lipotype, I enjoy custom packages and great support!

    Olga Ramich

    DIfE
  • After moving from one continent to another, I still prefer Lipotype!

    Julie Jacquemyn

    University of Alberta
  • Thank you very much for my new and shiny lipidomics data set!

    Ilya Levental

    University of Virginia
  • Lipotype Lipidomics is instrumental to our studies of membranes.

    Christopher J Stefan

    University College London
  • Lipotype is truly dedicated to supporting scientists in their research.

    Anonymous

    Anonymous

Contact Lipotype