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We provide MS-based lipid analysis of dhCer sphingolipids in a variety of sample types and deliver results in six or less weeks.


Lipid Category
Ceramide Lipids
Lipid Group
Lipid Class

About the structure and biological function of dhCer

Structure. Dihydroceramides (N-acyl-sphinganines, or dhCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. In animals, dihydroceramides are primarily synthesized in the endoplasmic reticulum, and may then serve as biosynthetic precursor to ceramides. In comparison to ceramides, the absence of the double bond in the sphingoid base of dihydroceramides affects the biophysical properties of membranes rich in dhCer. They are linked to the production of reactive oxygen species in mitochondria, inducing and rectifying apoptosis, and accumulation of dhCer in the nervous system can lead to neuronal dysfunction.

dhCer lipidomics analysis with

Structural detailsmolecular species
Variants identified > 10
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Delivery time6 weeks
Lipidomics datapmol & mol%


An example for the molecular structure of dihydroceramide, specifically Cer(d18:0/20:0).


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