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Sphinganine-phosphate

We provide MS-based lipid analysis of dhSphP sphingolipids in a variety of sample types and deliver results in six or less weeks.
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Details

Sphingolipids
Lipid Category
Sphingoid Bases
Lipid Group
Sphinganine-phosphate
Lipid Class

About the structure and biological function of dhSphP

Structure. Sphinganine-phosphates (dihydrosphingosine-phosphates, sphinganine-1-phosphates, or dhSphP) belong to the group of sphingoid bases within the sphingolipids. Their structure consists of an amino alcohol with a saturated hydrocarbon chain linked to a phosphate molecule.

Function. Little is known about the function of sphinganine-phosphates. However, they have been implicated in the protection of kidney and liver after hepatic ischemia and reperfusion, a major complication after liver transplantation. Futher, sphinganine-phosphate levels may serve as a biomarker for fumonisin exposure, a group of mycotoxins produced by fungi of the genus fusarium.

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dhSphP lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
dhSphP

An example for the molecular structure of sphinganine-phosphate, specifically SPBP 18:0;O2.

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dhSphP
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Groups

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Classes

FFA BCFA SCFA MCFA LCFA VLCFA oxiFAL WE CAR NAE oxiHTrE oxiOME oxiODE oxiOTrE Pgd LT TX LX IsoP RvE oxiEDE oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE oxiChol Lano Desm Lath Erg EE C10T C15T Sqe oxiSqe UQ
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