Non-hydroxy-phytosphingosine

We provide MS-based lipid analysis of NP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of NP

Structure. Non-hydroxy-fatty acid [N] phytosphingosine [P] ceramides (CER[NP], or NP) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The function of non-hydroxy-phytosphingosines is tightly linked to skin health where they serve structural and signaling roles. NP ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Increased NP levels are associated with psoriasis. Further, NP ceramides are decreased in Albino African skin.

NP lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH, Chol, CE

STRUCTURE
NP

General molecular structure of non-hydroxy-phytosphingosine.

EXAMPLE
NP 18:0;3/30:0;0

An example for the molecular structure of non-hydroxy-phytosphingosine, specifically NP 18:0;3/30:0;0.

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