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Non-hydroxy-phytosphingosine
We provide MS-based lipid analysis of NP ceramides in a variety of sample types and deliver results in as little as three weeks.
About the structure and biological function of NP
Structure. Non-hydroxy-fatty acid [N] phytosphingosine [P] ceramides (CER[NP], or NP) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. The function of non-hydroxy-phytosphingosines is tightly linked to skin health where they serve structural and signaling roles. NP ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. Skin ceramide imbalances can lead or contribute to the development of skin conditions. Increased NP levels are associated with psoriasis. Further, NP ceramides are decreased in Albino African skin.
NP lipidomics analysis with
Structural details subspecies level Variants identified > 250 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
EXAMPLE STRUCTURENP
EXAMPLENP 18:0;3/30:0;0
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