Eicosanoids

We provide MS-based lipid analysis of eicosanoids in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group

About the structure and biological function of Eicosanoids

Structure. Eicosanoids belong to the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. Eicosanoids, docosanoids, octadecanoids, and further lipid groups are collectively termed oxylipins. Their hydrocarbon chain features oxygen-containing substituents, they are oxidized fatty acyls. Typically, eicosanoids contain multiple double bonds.

Function. Eicosanoids are found in eukaryotes such as animals, plants, and fungi, but rarely in prokaryotes. In cells, they are often in free form or linked to phospholipids to be released on demand. The composition of the hydrocarbon chain largely defines their biological function. Prostaglandins (PG), leukotrienes (LT), and lipoxins (LX) are probably the most prominent eicosanoids. They are well-known for their capacity to modify inflammatory responses.

Thromboxanes (TX) are noted for their role in platelet aggregation. Isoprostanes (IsoP) are the ‘gold standard’ for non-invasive measurement of oxidative stress. Oxidized eisocatrienoic (oxiETrE), eicosatetraenoic (oxiETE), and eicosapentaenoic acids (oxiPETE) serve diverse roles from being precursors to other eicosanoids and exerting signaling functions to modifying inflammation.

Eicosanoids lipidomics analysis with Lipotype

Covered classes8
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

STRUCTURE
Eicosanoids

General molecular structure of the lipid group eicosanoids.

ABOUT LIPOTYPE

Lipotype logo with Claim, 600 dpi

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

Request analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!