Alpha-hydroxy-6-hydroxysphingosine

We provide MS-based lipid analysis of AH skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

About the structure and biological function of AH

Structure. Alpha-hydroxy-fatty acid [A] 6-hydroxy-sphingosine [H] ceramides (CER[AH], or AH) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological roles of alpha-hydroxy-6-hydroxy-sphingosines are tightly linked to skin health where they fulfill structural and signaling purposes. AH ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. They are critical for barrier homeostasis. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Further, AH ceramides are increased in Albino African skin.

AH lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH, Chol, CE

STRUCTURE
AH

General molecular structure of alpha-hydroxy-6-hydroxy-sphingosines.

EXAMPLE
AH 18:1;3/28:0;1

An example for the molecular structure of alpha-hydroxy-6-hydroxy-sphingosines, specifically AH 18:1;3/28:0;1.

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