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Alpha-hydroxy-6-hydroxysphingosine
We provide MS-based lipid analysis of AH ceramides in a variety of sample types and deliver results in as little as three weeks.
About the structure and biological function of AH
Structure. Alpha-hydroxy-fatty acid [A] 6-hydroxy-sphingosine [H] ceramides (CER[AH], or AH) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. The biological roles of alpha-hydroxy-6-hydroxy-sphingosines are tightly linked to skin health where they fulfill structural and signaling purposes. AH ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. They are critical for barrier homeostasis. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Further, AH ceramides are increased in Albino African skin.
AH lipidomics analysis with
Structural details subspecies level Variants identified > 250 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
EXAMPLE STRUCTUREAH
EXAMPLEAH 18:1;3/28:0;1
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