About the structure and biological function of oxiSqe
Structure. Oxidized squalenes (oxidosqualenes, or oxiSqe) belong to the group of isoprenoids within the prenol lipids category. Their structure is based on a linear chain of six five-carbon isoprene units, the building blocks of prenol lipids. Oxidized squalenes further encompass oxygen containing substituents such as hydroxyl and epoxy groups.
Function. Depending on their oxygen containing substituents, oxidized squalenes fulfill multiple biological roles such as occupying an intermediary branch point in the biosynthesis of sterol lipids in plants and animals. Following UV exposure, oxiSqe are exerting harmful activities in mammal skin: they can contribute to an increase in the release of inflammatory mediators and sebaceous gland proliferation. Further, changes in levels of oxidized squalenes are believed to relate to juvenile and adult acne.
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