GM2 Ganglioside

We provide MS-based lipid analysis of GM2 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group
GM2 Ganglioside
Lipid Class

About the structure and biological function of GM2

Structure. GM2 ganglioside lipids belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of four sugar molecules. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GM2 gangliosides are components of the cell membrane and may suppress malignant properties of various cancers. The mechanism is suggested to be due to complex formation at the cell surface with membrane proteins. Genetic defects leading to accumulation of GM2, due to increased lysosomal storage  cause Tay-Sachs, Sandhoff and AB variant disease. Further, GM2 lipids bind to a toxin secreted by Clostridium perfringens.

GM2 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
Gb3, DiHexCer, Gb4, GM1, GM2, Sulf, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1

STRUCTURE
GM2

General molecular structure of the ganglioside GM2.

EXAMPLE
GM2 38:1;2

An example for the molecular structure of ganglioside GM2, specifically GM2 38:1;2.

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