Sphingolipids
Details
Lipid Category
About the structure and biological function of Sphingolipids
Structure. Sphingolipids are one of the eight categories of lipids and contain tens of thousands of lipid species. All of these feature a similar molecular structure: they consist of a ceramide backbone linked to a hydrocarbon chain termed long-chain base. A variety of “head” groups can be linked to the ceramide backbone, as well as a two fatty acid.
Function. Sphingolipids are present in all animals and plants and may be found in some fungi and bacteria. They are functional components of mainly cell membranes. However, great variability may apply regarding the types of findable sphingolipids in an organism. Ceramides are sphingolipids featuring a relatively simple structure. They serve as biosynthetic precursors to complex sphingolipids and are vital skin constituents.
Gangliosides, cerebrosides, and sulfoglycosphingolipids all feature some form of sugar head group and are crucial to the nervous system. Phosphosphingolipids are essential to lipid raft formation, functional subdomains of the cell membrane. The sphingolipid types globosides and diglycosylceramides serve important roles in the immune system.
Sphingolipids lipidomics analysis with Lipotype
| Covered classes | 34 |
| Approach | untargeted |
| Method | mass spectrometry |
| Device | Q Exactive Orbitrap (280.000 Res) |
| Quantification | yes |
| Delivery time | 2-6 weeks |
| Lipidomics data | pmol & mol% |
CORE STRUCTURE
Sphingolipids
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