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Sphingolipids

We provide MS-based lipid analysis of sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category

About the structure and biological function of Sphingolipids

Structure. Sphingolipids are one of the eight categories of lipids and contain tens of thousands of lipid species. All of these feature a similar molecular structure: they consist of a sphingoid base or long-chain base, an amino alcohol with a hydrocarbon chain. A variety of “head” groups can be linked to the sphingoid base, as well as a two fatty acids.

Function. Sphingolipids are present in all animals and plants and may be found in some fungi and bacteria. They are functional components of mainly cell membranes. However, great variability may apply regarding the types of findable sphingolipids in an organism. Ceramides are sphingolipids featuring a relatively simple structure. They serve as biosynthetic precursors to complex sphingolipids and are vital skin constituents.

Gangliosides, cerebrosides, and sulfoglycosphingolipids all feature some form of sugar head group and are crucial to the nervous system. Phosphosphingolipids are essential to lipid raft formation, functional subdomains of the cell membrane. The sphingolipid types globosides and diglycosylceramides serve important roles in the immune system.

Sphingolipids lipidomics analysis with Lipotype

Covered classes 46
Approach untargeted/targeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
or
Agilent 1290 HPLC + 6495 Triplequad
Quantification yes
Delivery time 2-6 weeks
Lipidomics data pmol & mol%

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    Yale University
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    DIfE
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    University of Alberta
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    University of Virginia
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    University College London
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