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We provide MS-based lipid analysis of GlcSph sphingolipids in a variety of sample types and deliver results in six or less weeks.


Lipid Category
Sphingoid Bases
Lipid Group

About the structure and biological function of GlcSph

Structure. Glucosylsphingosines (glucosyl-sphing-4-enines, glucosphingosines, lyso-Gb1, or GlcSph) belong to the group of sphingoid bases within the sphingolipids. Their structure consists of an amino alcohol with a monounsaturated hydrocarbon chain linked to a glucose molecule.

Function. The biological role of glucosylsphingosines has been mostly associated with Gaucher disease, a rare genetic disorder and lysosomal storage disease during which GlcSph accumulates among other sphingolipids. Further, they have been associated with tumor progression in melanoma and glusosylsphingosines are also associated with activating an itch-scratch response pathway in atopic dermatitis.

GlcSph lipidomics analysis with

Structural detailsmolecular species
Variants identified < 10
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Delivery time6 weeks
Lipidomics datapmol & mol%


An example for the molecular structure of glucosylsphingosine, specifically GlcSph.


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