Ether-linked lyso-phosphatidylcholine

We provide MS-based lipid analysis of LPC O- phospholipids in a variety of sample types and deliver results in as little as two weeks.

About the structure and biological function of LPC O-

Structure. Ether-linked lyso-phosphatidyl-cholines (lysoPAF, or LPC O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-cholines. They are precursors to ether-linked phosphatidylcholines and to platelet activating factor (PAF), which is important for inflammatory reactions but also structure and function of the central nervous system. Elevated levels of LPC O- lipids have been found in patients with Alzheimer’s disease.

LPC O- lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
PC O-, CL, Cer, HexCer, PE O-, LPC O-, LPE O-, LPA, LPC, LPE, LPG, LPI, LPS

2Blood Extended includes:
HexCer, PA, LPC O-, LPE O-, PG, LPA, LPI

STRUCTURE
LPC O-

General molecular structure of ether-linked lyso-phosphatidylcholine.

EXAMPLE
LPC O- 15:0;0

An example for the molecular structure of ether-linked lyso-phosphatidylcholine, specifically LPC O- 15:0;0.

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