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Ether-linked Lyso-phosphatidylcholine
We provide MS-based lipid analysis of LPC O- phospholipids in a variety of sample types and deliver results in as little as two weeks.
About the structure and biological function of LPC O-
Structure. Ether-linked lyso-phosphatidyl-cholines (lysoPAF, or LPC O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-cholines. They are precursors to ether-linked phosphatidylcholines and to platelet activating factor (PAF), which is important for inflammatory reactions but also structure and function of the central nervous system. Elevated levels of LPC O- lipids have been found in patients with Alzheimer’s disease.
LPC O- lipidomics analysis with
Structural details species level Variants identified > 25 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 2-6 weeks Lipidomics data pmol & mol% Figures included
1 Cells Extended includes:2 Blood Extended includes:
EXAMPLE STRUCTURELPC O-
EXAMPLELPC O- 15:0;0
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