Ether-linked Lyso-phosphatidyl­choline

We provide MS-based lipid analysis of LPC O- phospholipids in a variety of sample types and deliver results in as little as two weeks.
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Details

Phospholipids
Lipid Category
Ether Phospholipids
Lipid Group
Ether-linked Lyso-phosphatidyl­choline
Lipid Class

About the structure and biological function of LPC O-

Structure. Ether-linked lyso-phosphatidyl-cholines (lysoPAF, or LPC O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphocholine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-cholines. They are precursors to ether-linked phosphatidylcholines and to platelet activating factor (PAF), which is important for inflammatory reactions but also structure and function of the central nervous system. Elevated levels of LPC O- lipids have been found in patients with Alzheimer’s disease.

Research articles

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Ether-linked Lyso-phosphatidyl­choline lipidomics analysis with Lipotype

Structural details species level
Variants identified > 25
Approach untargeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
Quantification yes
Delivery time 2-6 weeks
Lipidomics data pmol & mol%
Figuresyes
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, PC O-, PE O-, LPC O-, LPE O-, CL, Cer, HexCer

2Blood Extended includes:
PA, PG, LPA, LPI, LPC O-, LPE O-, HexCer

Example Structure
LPC O-

An example for the molecular structure of ether-linked lyso-phosphatidylcholine, specifically LPC O- 15:0;0.

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LPC O-
analysis?

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Categories

Fatty AcylsGlycerolipidsPhospholipidsSphingolipidsSterol LipidsPrenol Lipids

Groups

Fatty AcidsFatty AldehydesFatty EstersFatty AmidesHeptadecanoidsOctadecanoidsEicosanoidsDocosanoidsGlycerol EstersEster PhospholipidsEther PhospholipidsDiphospha­tidyl­glycerolsCDP-GlycerolsSphingoid BasesCeramide LipidsCerebrosidesDiglycosyl­ceramidesPhospho­sphingolipidsGangliosidesGlobosidesSulfoglyco­sphingolipidsCholesterol LipidsErgosterol LipidsIsoprenoidsQuinones

Classes

FFABCFASCFAMCFALCFAVLCFAoxiFALWECARNAEoxiHTrEoxiOMEoxiODEoxiOTrEPgdLTTXLXIsoPRvEoxiEDEoxiETrEoxiETEoxiEPEMaRRvDPDoxiDPAoxiDHATAGDAGMAGPAPCPEPGPIPSLPALPCLPELPGLPILPSBMPPC O-PE O-LPC O-LPE O-CLCDP-DAGSphdhSphSphPdhSphPGlcSphGalSphCerCerPdhCerdoxCerEOdSEOSEOPEOHNdSNSNPNHAdSASAPAHHexCerGlcCerGalCerDiHexCerLacCerSMCerPEIPCMIPCM(IP)2CGM1GM2GM3GM4GD1GD2GD3GT1GT2GT3GQ1Gb3Gb4SulfCholCEoxiCholLanoDesmLathErgEEC10TC15TSqeoxiSqeUQ
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