Leukotriene

We provide MS-based lipid analysis of LT fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group
Leukotriene
Lipid Class

About the structure and biological function of LT

Structure. Leukotrienes (LT) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains four double bonds of which three are in conjugation. The hydrocarbon chain of LTs can contain further double bonds and oxygen containing substituents.

Function. Leukotrienes exert hormone-like functions. They interact with G-protein-linked receptors on the cell surface to activate signal transduction pathways inside the cell. Specifically, LTs modify pro- and anti-inflammatory responses. Leukotrienes stimulate cellular responses like attracting cells of the innate immune system to the site of insult or enhanced mucus secretion in the airways. Some LT species are linked to chronic inflammation and allergic diseases such as atherosclerosis and asthma.

LT lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
LT

An example for the molecular structure of leukotriene B4.

ABOUT LIPOTYPE

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