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GM3 Ganglioside

We provide MS-based lipid analysis of GM3 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group
GM3 Ganglioside
Lipid Class

About the structure and biological function of GM3

Structure. GM3 ganglioside lipids belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of three sugar molecules. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GM3 lipids are the simplest gangliosides chemically and serve as precursors of more complex gangliosides but also fulfill a structural role themselves. In the cell membrane, they associate with each other and other lipids into lipid rafts and caveolae. The concentration of GM3 in caveolae affects the activity of receptors involved in the regulation of glucose uptake. They also are critical for cochlear hair cells and essential for hearing. Further, modified GM3 lipids are found in many cancers, including melanomas and stage II breast cancers.

GM3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified >50
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Gb3, Gb4, Sulf

EXAMPLE STRUCTURE
GM3

An example for the molecular structure of ganglioside GM3, specifically GM3 32:1;2.

EXAMPLE
GM3 38:1;2

An example for the molecular structure of ganglioside GM3, specifically GM3 38:1;2.

ABOUT LIPOTYPE

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    Friedrich Miescher Institute
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