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Phosphatidate
We provide MS-based lipid analysis of PA phospholipids in a variety of sample types and deliver results in as little as two weeks.
About the structure and biological function of PA
Structure. Phosphatidates (phosphatidic acids, PtdOH, or PA) belong to the group of ester phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to two fatty acids and a phosphate group. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Function. Phosphatidates are key intermediates in the synthesis of other glycerophospholipids and triacylglycerols. Yet, phosphatidates modulate signaling and cellular processes such as vesicular trafficking, enzyme activity, as well as membrane structure and dynamics. They are activators of lipid-gated ion channels. They are also precursors of lyso-phosphatidates, which are key signaling molecules. Further, the reaction product of phosphatidates with ethanol is used as biomarker for alcohol consumption and they are the key plant lipid second messengers.
PA lipidomics analysis with
Structural details subspecies level Variants identified > 500 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 2-6 weeks Lipidomics data pmol & mol% Figures included
1 Cells Basic includes:2 Blood Extended includes:
EXAMPLE STRUCTUREPA
EXAMPLEPA 18:2;0_20:2;0
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