Ether-linked phosphatidylcholine

We provide MS-based lipid analysis of PC O- phospholipids in a variety of sample types and deliver results in as little as two weeks.

About the structure and biological function of PC O-

Structure. Ether-linked phosphatidyl-cholines (plasmanyl-phosphatidylcholines, alkyl-phosphatidylcholines, Platelet Activating Factor, PAF, or PC O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty acid, a fatty alcohol and a phosphocholine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.

Function. Ether-linked phosphatidyl-cholines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PC O- lipids are reduced in the blood of patients with multiple sclerosis. On the other hand, elevated levels have been found in cancers, especially in aggressive forms. Further, PC O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.

PC O- lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
PC O-, CL, Cer, HexCer, PE O-, LPC O-, LPE O-, LPA, LPC, LPE, LPG, LPI, LPS

2Blood Basic includes:
PC O-, SM, Cer, TAG, DAG, PC, PE O-, PE, PI, LPC, LPE, Chol, CE

STRUCTURE
PC O-

General molecular structure of ether-linked phosphatidylcholine.

EXAMPLE
PC O- 18:0;0/22:5;0

An example for the molecular structure of ether-linked phosphatidylcholine, specifically PC O- 18:0;0/22:5;0.

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