Alpha-hydroxy-sphingosine

We provide MS-based lipid analysis of AS ceramides in a variety of sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of AS

Structure. Alpha-hydroxy-fatty acid [A] sphingosine [S] ceramides (CER[AS], or AS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Alpha-hydroxy-sphingosines are mostly important for skin health where they serve structural and signaling roles. AS ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide imbalances can lead or contribute to the development of skin conditions. AS levels are reduced in psoriasis and dry skin. Further, AS ceramides are increased in Albino African skin.

Alpha-hydroxy-sphingosine lipidomics analysis with Lipotype

Structural details subspecies level
Variants identified > 100
Approach untargeted
Method mass spectrometry
Device Q Exactive Orbitrap (280.000 Res)
Quantification yes
Delivery time 3-6 weeks
Lipidomics data pmol & mol%
Figuresyes
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

Example Structure
AS

An example for the molecular structure of alpha-hydroxy-sphingosines, specifically AS 16:1;2/24:0;1.

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