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Alpha-hydroxy-sphingosine
We provide MS-based lipid analysis of AS ceramides in a variety of sample types and deliver results in as little as three weeks.
About the structure and biological function of AS
Structure. Alpha-hydroxy-fatty acid [A] sphingosine [S] ceramides (CER[AS], or AS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. Alpha-hydroxy-sphingosines are mostly important for skin health where they serve structural and signaling roles. AS ceramides are involved in the formation of the epidermal barrier which protects against the environment and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide imbalances can lead or contribute to the development of skin conditions. AS levels are reduced in psoriasis and dry skin. Further, AS ceramides are increased in Albino African skin.
AS lipidomics analysis with
Structural details subspecies level Variants identified > 100 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
EXAMPLE STRUCTUREAS
EXAMPLEAS 16:1;2/24:0;1
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