Home   Lipotype Lipidomics   Sphingolipids   Ceramide Lipids   EOH 

Omega-hydroxy-6-hydroxysphingosine

We provide MS-based lipid analysis of EOH ceramides in a variety of sample types and deliver results in as little as three weeks.

About the structure and biological function of EOH

Structure. Omega-hydroxy-fatty acid [EO] 6-hydroxy-sphingosine [H] ceramides (CER[EOH], or EOH) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically 6-hydroxy-sphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Omega-hydroxy-6-hydroxy-sphingosines are mostly important for human skin where they serve mainly structural roles. EOH ceramides are critical to the lamellar phase of the epidermal barrier function to prevent trans-epidermal water loss but also protect against the environment. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Reduced levels of EOH ceramides are linked to psoriasis and dry skin. Further, EOH lipids are increased in Albino African skin.

EOH lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

EXAMPLE STRUCTURE
EOH

An example for the molecular structure of omega-hydroxy-6-hydroxy-sphingosines, specifically EOH 68:3;3.

EXAMPLE
EOH 68:3;3

An example for the molecular structure of omega-hydroxy-6-hydroxy-sphingosines, specifically EOH 68:3;3.

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

  • Thank you once again. The timing is extremely helpful to us.

    Susan Macdonald

    Aldeyra Therapeutics
  • Thank you very much. The results look fantastic!

    Stan Neufeld

    Friedrich Miescher Institute
  • The high-speed turn around when under revision really helped us!

    Rose E Goodchild

    KU Leuven
  • We highly appreciate the personal support and consultation.

    Rainer Voegeli

    DSM Skin Biology
  • We have been quite impressed. The results clearly indicate a difference.

    Pietro De Camilli

    Yale University
  • Cooperating with Lipotype, I enjoy custom packages and great support!

    Olga Ramich

    DIfE
  • After moving from one continent to another, I still prefer Lipotype!

    Julie Jacquemyn

    University of Alberta
  • Thank you very much for my new and shiny lipidomics data set!

    Ilya Levental

    University of Virginia
  • Lipotype Lipidomics is instrumental to our studies of membranes.

    Christopher J Stefan

    University College London
  • Lipotype is truly dedicated to supporting scientists in their research.

    Anonymous

    Anonymous

Request Analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!