About the structure and biological function of EOP
Structure. Omega-hydroxy-fatty acid [EO] phytosphingosine [P] ceramides (CER[EOP], or EOP) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. The role of omega-hydroxy-phytosphingosines is mostly associated with human skin where they fulfill mainly structural purposes. EOP ceramides are relevant to the formation of the lamellar phase of the epidermal barrier to prevent trans-epidermal water loss but also protect against the environment. Skin ceramide profile aberrations can lead or contribute to skin conditions. In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.
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