Omega-hydroxy-phytosphingosine

We provide MS-based lipid analysis of EOP skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of EOP

Structure. Omega-hydroxy-fatty acid [EO] phytosphingosine [P] ceramides (CER[EOP], or EOP) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The role of omega-hydroxy-phytosphingosines is mostly associated with human skin where they fulfill mainly structural purposes. EOP ceramides are relevant to the formation of the lamellar phase of the epidermal barrier to prevent trans-epidermal water loss but also protect against the environment. Skin ceramide profile aberrations can lead or contribute to skin conditions.  In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.

EOP lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH, Chol, CE

STRUCTURE
EOP

General molecular structure of omega-hydroxy-phytosphingosines.

EXAMPLE
EOP 68:2;3

An example for the molecular structure of omega-hydroxy-phytosphingosines, specifically EOP 68:2;3.

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