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Gb4 Globoside

We provide MS-based lipid analysis of Gb4 globosides in a variety of sample types and deliver results in as little as two weeks.


Lipid Category
Lipid Group
Gb4 Globoside
Lipid Class

About the structure and biological function of Gb4

Structure. Gb4 globoside lipids (globo-tetraosylceramides, or cytolipin R) belong to the group of globosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral oligosaccharide unit made of four sugar molecules. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Gb4 globosides are the main glycolipids found in the cell membrane of human erythrocytes. There, they are important for cellular interactions including blood-type determinants, factors which determine the suitability of donor blood for a patient. Each of the three distinct blood group antigens (A, B, and 0) is defined by a variation of the oligosaccharide unit. Gb4 lipids also act as the receptor for the parvovirus B19, which infects rapidly dividing cells of the intestines and the bone marrow causing (fifth disease) in children.

Gb4 lipidomics analysis with

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Delivery time2-4 weeks
Lipidomics datapmol & mol%
1Glycosphingolipids includes:
DiHexCer, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Gb3, Gb4, Sulf


An example for the molecular structure of globoside Gb4, specifically Gb4 44:1;2.

Gb4 36:1;2

An example for the molecular structure of globoside Gb4, specifically Gb4 36:1;2.


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