Gb4 Globoside
Details
Lipid Category
Lipid Group
Lipid Class
About the structure and biological function of Gb4
Structure. Gb4 globoside lipids (globo-tetraosylceramides, or cytolipin R) belong to the group of globosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral oligosaccharide unit made of four sugar molecules. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.
Function. Gb4 globosides are the main glycolipids found in the cell membrane of human erythrocytes. There, they are important for cellular interactions including blood-type determinants, factors which determine the suitability of donor blood for a patient. Each of the three distinct blood group antigens (A, B, and 0) is defined by a variation of the oligosaccharide unit. Gb4 lipids also act as the receptor for the parvovirus B19, which infects rapidly dividing cells of the intestines and the bone marrow causing (fifth disease) in children.
Gb4 lipidomics analysis with
Lipotype
Structural details | species level |
Variants identified | > 10 |
Approach | untargeted |
Method | mass spectrometry |
Device | Q Exactive Orbitrap (280.000 Res) |
Quantification | yes |
Delivery time | 2-4 weeks |
Lipidomics data | pmol & mol% |
Figures | included |
DiHexCer, Gb3, Gb4, Sulf
EXAMPLE STRUCTURE
Gb4

Interested in
Gb4
analysis?
Lipid Inspector
Groups
Classes
Learn more about our Name lipidomics analysis service.
Show infosRequest analysis
You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!