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Cardiolipin
We provide MS-based lipid analysis of CL phospholipids in a variety of sample types and deliver results in as little as two weeks.
About the structure and biological function of CL
Structure. Cardiolipins (Ptd2Gro, or CL) belong to the group of diphosphatidylglycerols within the phospholipids. Their structure consists of two diacylglycerophosphates linked to each other via a third glycerol backbone. In total, cardiolipins contain four ester-linked fatty acids. They can be of variable length, hydroxylated, and contain double bonds.
Function. Cardiolipins are tied to the synthesis of ATP, cellular energy. They are a vital component of cellular membranes whose function is to generate an electrochemical potential, such as mitochondrial membranes. There, they interact with many membrane proteins regulating and controlling their functions. They are also involved in apoptosis and mitophagy, programmed cell death and mitochondrial degradation. Further, cardiolipin aberrations are linked to Barth syndrome, cancer, diabetes, and Parkinson’s disease.
CL lipidomics analysis with
Structural details species level Variants identified > 250 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 2-6 weeks Lipidomics data pmol & mol% Figures included
1 Cells Extended includes:
EXAMPLE STRUCTURECL
EXAMPLECL 76:5;0
ABOUT LIPOTYPE
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