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We provide MS-based lipid analysis of CL phospholipids in a variety of sample types and deliver results in as little as two weeks.


Lipid Category
Lipid Class

About the structure and biological function of CL

Structure. Cardiolipins (Ptd2Gro, or CL) belong to the group of diphosphatidylglycerols within the phospholipids. Their structure consists of two diacylglycerophosphates linked to each other via a third glycerol backbone. In total, cardiolipins contain four ester-linked fatty acids. They can be of variable length, hydroxylated, and contain double bonds.

Function. Cardiolipins are tied to the synthesis of ATP, cellular energy. They are a vital component of cellular membranes whose function is to generate an electrochemical potential, such as mitochondrial membranes. There, they interact with many membrane proteins regulating and controlling their functions. They are also involved in apoptosis and mitophagy, programmed cell death and mitochondrial degradation. Further, cardiolipin aberrations are linked to Barth syndrome, cancer, diabetes, and Parkinson’s disease.

CL lipidomics analysis with

Structural detailsspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Delivery time2-6 weeks
Lipidomics datapmol & mol%
1Cells Extended includes:
LPA, LPC, LPE, LPG, LPI, LPS, PC O-, PE O-, LPC O-, LPE O-, CL, Cer, HexCer


An example for the molecular structure of cardiolipin, specifically CL 69:4;0.

CL 76:5;0

An example for the molecular structure of cardiolipin, specifically CL 76:5;0.


Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    Yale University
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    University of Alberta
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    University of Virginia
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    University College London
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