Cardiolipin

We provide MS-based lipid analysis of CL phospholipids in a variety of sample types and deliver results in as little as two weeks.

Details

Phospholipids
Lipid Category
Cardiolipin
Lipid Class

About the structure and biological function of CL

Structure. Cardiolipins (Ptd2Gro, or CL) belong to the group of diphosphatidylglycerols within the phospholipids. Their structure consists of two diacylglycerophosphates linked to each other via a third glycerol backbone. In total, cardiolipins contain four ester-linked fatty acids. They can be of variable length, hydroxylated, and contain double bonds.

Function. Cardiolipins are tied to the synthesis of ATP, cellular energy. They are a vital component of cellular membranes whose function is to generate an electrochemical potential, such as mitochondrial membranes. There, they interact with many membrane proteins regulating and controlling their functions. They are also involved in apoptosis and mitophagy, programmed cell death and mitochondrial degradation. Further, cardiolipin aberrations are linked to Barth syndrome, cancer, diabetes, and Parkinson’s disease.

CL lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
PC O-, CL, Cer, HexCer, PE O-, LPC O-, LPE O-, LPA, LPC, LPE, LPG, LPI, LPS

STRUCTURE
CL

General molecular structure of cardiolipin.

EXAMPLE
CL 76:5;0

An example for the molecular structure of cardiolipin, specifically CL 76:5;0.

ABOUT LIPOTYPE

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