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Resolvin E

We provide MS-based lipid analysis of RvE fatty acyls in a variety of sample types and deliver results in six or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group
Resolvin E
Lipid Class

About the structure and biological function of RvE

Structure. Resolvin Es (RvE) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains five double bonds of which at least three are in conjugation. RvEs contain at least two hydroxyl groups but can feature additional hydroxylations and further oxygen containing substituents. They differ from maresins and resolvin Ds in their biosynthetic route.

Function. Like resolvin Ds, resolvin Es belong to the ‘Specialized Pro-resolving Mediators’ (SPMs), a set of fatty acyl lipids which significantly impact the resolution of inflammation. To exert their pro-resolving activity, RvEs interact with specific G-protein-coupled receptors. As part of the innate immune system, they take part in the resolution of inflammation through the release of interleukin 10. Resolvin Es have been linked to control of vascular inflammation and protection against atherosclerosis.

RvE lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

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