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Lipoxin
We provide MS-based lipid analysis of LX fatty acyls in a variety of sample types and deliver results in eight or less weeks.
About the structure and biological function of LX
Structure. Lipoxins (LX) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains four double bonds in conjugation, and further features three hydroxy groups.
Function. The biological role of lipoxins mainly revolves around the resolution of inflammation. They interact with specific cell membrane embedded G-protein-linked receptors to activate signal transduction pathways in the cell. For example, LXs control the entry of neutrophils to sites on inflammation, an essential cell type of the innate immune system which is prone to causing collateral damage during prolonged activity. Further, dysregulated lipoxin function is linked to Alzheimer’s disease.
LX lipidomics analysis with
Structural details molecular species Variants identified < 10 Approach targeted Method mass spectrometry Device Agilent 1290 HPLC + 6495 Triplequad Quantification yes Delivery time 6 weeks Lipidomics data pmol & mol% Figures in development
EXAMPLE STRUCTURELX
ABOUT LIPOTYPE
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