Lipoxin

We provide MS-based lipid analysis of LX fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group
Lipoxin
Lipid Class

About the structure and biological function of LX

Structure. Lipoxins (LX) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains four double bonds in conjugation, and further features three hydroxy groups.

Function. The biological role of lipoxins mainly revolves around the resolution of inflammation. They interact with specific cell membrane embedded G-protein-linked receptors to activate signal transduction pathways in the cell. For example, LXs control the entry of neutrophils to sites on inflammation, an essential cell type of the innate immune system which is prone to causing collateral damage during prolonged activity. Further, dysregulated lipoxin function is linked to Alzheimer’s disease.

LX lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
LX

An example for the molecular structure of LXA4.

ABOUT LIPOTYPE

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