Protectin

We provide MS-based lipid analysis of PD fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Docosanoids
Lipid Group
Protectin
Lipid Class

About the structure and biological function of PD

Structure. Protectins (PD) belong to the group of docosanoids within the fatty acyls. Their structure is based on docosanoic acid, a twenty-two carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains six double bonds of which three are in conjugation. The hydrocarbon chain of PDs can further feature oxygen containing substituents.

Function. Protectins are lipid mediators with significant inflammation-resolving and neuroprotective activities which they exert by interacting with specific G-protein-coupled receptors. They are part of the ‘Specialized Pro-resolving Mediators’ (SPMs), a small set of fatty acyl lipids which are intimately involved in the resolution of inflammation, and thus clearing the effects of pro-inflammatory fatty acyls, such as leukotrienes and prostaglandins.

PD lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
PD

An example for the molecular structure of protectin D1.

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