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Protectin

We provide MS-based lipid analysis of PD fatty acyls in a variety of sample types and deliver results in six or less weeks.
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Details

Fatty Acyls
Lipid Category
Docosanoids
Lipid Group
Protectin
Lipid Class

About the structure and biological function of PD

Structure. Protectins (PD) belong to the group of docosanoids within the fatty acyls. Their structure is based on docosanoic acid, a twenty-two carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains six double bonds of which three are in conjugation. The hydrocarbon chain of PDs can further feature oxygen containing substituents.

Function. Protectins are lipid mediators with significant inflammation-resolving and neuroprotective activities which they exert by interacting with specific G-protein-coupled receptors. They are part of the ‘Specialized Pro-resolving Mediators’ (SPMs), a small set of fatty acyl lipids which are intimately involved in the resolution of inflammation, and thus clearing the effects of pro-inflammatory fatty acyls, such as leukotrienes and prostaglandins.

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PD lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
PD

An example for the molecular structure of protectin D1.

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PD
analysis?

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Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Aldehydes Fatty Esters Fatty Amides Heptadecanoids Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA BCFA SCFA MCFA LCFA VLCFA oxiFAL WE CAR NAE oxiHTrE oxiOME oxiODE oxiOTrE Pgd LT TX LX IsoP RvE oxiEDE oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE oxiChol Lano Desm Lath Erg EE C10T C15T Sqe oxiSqe UQ
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