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Ceramide Phosphoethanolamine

We provide MS-based lipid analysis of CerPE sphingolipids in a variety of sample types and deliver results in as little as two weeks.
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Details

Sphingolipids
Lipid Category
Phospho­sphingolipids
Lipid Group
Ceramide Phosphoethanolamine
Lipid Class

About the structure and biological function of CerPE

Structure. Ceramide phosphoethanolamines (CerPE) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylethanolamine molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds. 

Function. Ceramide phosphoethanolamines are the sphingomyelin analogue of insects and some bacteria. In insects, it serves an important role in the functional equivalent of myelin, the insulating layer that forms around the axons of neurons. CerPEs further play a key role in the cell membrane of insects, where they impact membrane properties such as packaging and fluidity. Interestingly, CerPE producing bacteria belong mainly to the Bacteroidetes, which are dominant in the mammalian gut. 

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CerPE lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
CerPE

An example for the molecular structure of ceramide phosphoethanolamine, specifically CerPE 34:1;0.

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Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Aldehydes Fatty Esters Fatty Amides Heptadecanoids Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA BCFA SCFA MCFA LCFA VLCFA oxiFAL WE CAR NAE oxiHTrE oxiOME oxiODE oxiOTrE Pgd LT TX LX IsoP RvE oxiEDE oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE oxiChol Lano Desm Lath Erg EE C10T C15T Sqe oxiSqe UQ
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