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Maresin
We provide MS-based lipid analysis of MaR fatty acyls in a variety of sample types and deliver results in eight or less weeks.
About the structure and biological function of MaR
Structure. Maresins (MaR) belong to the group of docosanoids within the fatty acyls. Their structure is based on docosanoic acid, a twenty-two carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains six double bonds of which at least three are in conjugation. MaRs contain at least one oxygen containing substituent. They differ from resolvin Ds in their biosynthetic route.
Function. The biological function of maresins is linked to the resolution of inflammation. They are lipid mediators with interact with G-protein-coupled receptors and belong to the ‘Specialized Pro-resolving Mediators’ (SPMs), fatty acyls which resolve the pro-inflammatory activities of other fatty acyls, such as prostaglandins. MaRs are produced at the site of inflammation to help tissues to return to health and limiting the recruitment of pro-inflammatory immune cells.
MaR lipidomics analysis with
Structural details molecular species Variants identified < 10 Approach targeted Method mass spectrometry Device Agilent 1290 HPLC + 6495 Triplequad Quantification yes Delivery time 6 weeks Lipidomics data pmol & mol% Figures in development
EXAMPLE STRUCTUREMaR
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