Resolvin D

We provide MS-based lipid analysis of RvD fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Docosanoids
Lipid Group
Resolvin D
Lipid Class

About the structure and biological function of RvD

Structure. Resolvin Ds (RvD) belong to the group of docosanoids within the fatty acyls. Their structure is based on docosanoic acid, a twenty-two carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains six double bonds of which at least three are in conjugation. RvDs contain at least two hydroxyl groups but can feature additional hydroxylations and further oxygen containing substituents. They differ from maresins in their biosynthetic route.

Function. Resolvin Ds belong to the ‘Specialized Pro-resolving Mediators’ (SPMs), a set of fatty acyl lipids which significantly impact the resolution of inflammation. They are lipid mediators which interact with specific G-protein-coupled receptors to exert their pro-resolution activities. RvDs are part of the molecular mechanism to remove pro-inflammatory cells and restoration of tissue. They are also diminishing oxidative stress and impact many facets of the innate and adaptive immune system.

RvD lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
RvD

An example for the molecular structure of resolvin D5.

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