About the structure and biological function of oxiEDE
Structure. Oxidized eicosadienoic acids (oxiEDE) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains two double bonds, from which their name derives. OxiEDE may further encompass multiple hydroxy groups as well as other oxygen containing substituents.
Function. Oxidized eicosadienoic acids can influence the biosynthesis of long-chain polyunsaturated fatty acids and differentially affect pro-inflammatory mediators. Further, oxiEDE are investigated for their potential therapeutic role in Krabbe disease, a lysosomal storage disorder with neurological manifestation. In plants, bacteria, and fungi, oxidized eicosadienoic acids are known to be involved in environmental stress responses.