Sulfatide

We provide MS-based lipid analysis of Sulfatide in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Sulfatide
Lipid Class

About the structure and biological function of Sulfatide

Structure. Sulfatides (sulfated galactosyl-ceramides, sulfogalactosylceramides, galactosylceramide-sulfates, SO3-GalCer, or Sulf) belong to the group of sulfoglycosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone linked to a sulfated galactose sugar molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Sulfatides are a main constituent of myelin, the lipid coating around neuronal axons. Changes in brain sulfatide levels are linked to Alzheimer’s and Parkinson’s, and an abnormal sulfatide metabolism has been linked to cancers and autoimmune diseases. They also participate in many cellular processes from protein trafficking to signaling. Further, sulfatides are involved in the regulation of glucose uptake. Antibodies to sulfatides are often present in blood serum before the onset of diabetes.

Sulf lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, Sulf

EXAMPLE STRUCTURE
Sulf

An example for the molecular structure of sulfatide, specifically Sulf 42:2;2.

EXAMPLE
Sulf 36:1;3

An example for the molecular structure of sulfatide, specifically Sulf 36:1;3.

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