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Alpha-hydroxy-dihydrosphingosine

We provide MS-based lipid analysis of AdS ceramides in a variety of sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of AdS

Structure. Alpha-hydroxy-fatty acid [A] dihydro-sphingosine [dS] ceramides (CER[AdS], or AdS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological functions of alpha-hydroxy-dihydrosphingosines are mainly associated with human skin where they serve structural and signaling roles. AdS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. They are critical to barrier homeostasis. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. Further, AdS ceramides are decreased in Albino African skin.

AdS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

EXAMPLE STRUCTURE
AdS

An example for the molecular structure of alpha-hydroxy-dihydrosphingosines, specifically AdS 18:0;2/16:0;1.

EXAMPLE
AdS 18:0;2/16:0;1

An example for the molecular structure of alpha-hydroxy-dihydrosphingosines, specifically AdS 18:0;2/16:0;1.

ABOUT LIPOTYPE

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    Aldeyra Therapeutics
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    Friedrich Miescher Institute
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    KU Leuven
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    DSM Skin Biology
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    Yale University
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    DIfE
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    University of Alberta
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    University of Virginia
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    University College London
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