Ether-linked lyso-phosphatidylethanolamine

We provide MS-based lipid analysis of LPE O- phospholipids in a variety of sample types and deliver results in as little as two weeks.

About the structure and biological function of LPE O-

Structure. Ether-linked lyso-phosphatidyl-ethanolamines (LPE O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty alcohol via an ether bond and a phosphoethanolamine molecule. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the biological function of ether-linked lyso-phosphatidyl-ethanolamines, but they are precursors to ether-linked phosphatidyl-ethanolamines. In the pigmented layer of the human retina that nourishes retinal visual cells, LPE O- lipids are linked to the formation of bisretinoids. Bisretinoids are a family of fluorescent molecules that form in photoreceptor cells and contribute to some retinal diseases, thus LPE O- lipids are suggested to play a role in retinal health.

LPE O- lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
PC O-, CL, Cer, HexCer, PE O-, LPC O-, LPE O-, LPA, LPC, LPE, LPG, LPI, LPS

2Blood Extended includes:
HexCer, PA, LPC O-, LPE O-, PG, LPA, LPI

STRUCTURE
LPE O-

General molecular structure of ether-linked lyso-phosphatidylethanolamine.

EXAMPLE
LPE O- 18:1;0

An example for the molecular structure of ether-linked lyso-phosphatidylethanolamine, specifically LPE O- 18:1;0.

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