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Ether-linked phosphatidylethanolamine
We provide MS-based lipid analysis of PE O- phospholipids in a variety of sample types and deliver results in as little as two weeks.
About the structure and biological function of PE O-
Structure. Ether-linked phosphatidyl-ethanolamine (plasmanyl-phosphatidyl-ethanolamines, alkyl-phosphatidyl-ethanolamines, or PE O-) belong to the group of ether phospholipids within the phospholipids. Their structure consists of a glycerol backbone linked to a fatty acid, a fatty alcohol and a phosphoethanolamine molecule. One of the fatty acids is bound to the glycerol backbone via an ether bond. The fatty acids can be of variable length, hydroxylated, and contain double bonds.
Function. Ether-linked phosphatidyl-ethanolamines contain high amounts of arachidonic acid required for the biosynthesis of eicosanoids, bioactive lipids with a great role in inflammation. Levels of PE O- lipids are reduced in the blood of patients with multiple sclerosis. That said, elevated levels have been found in cancers, especially in aggressive forms. Further, PE O- lipids are important membrane constituents of neutrophils, the most abundant type of white blood cells in humans.
PE O- lipidomics analysis with
Structural details subspecies level Variants identified > 500 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 2-6 weeks Lipidomics data pmol & mol% Figures included
1 Cells Extended includes:2 Blood Basic includes:
EXAMPLE STRUCTUREPE O-
EXAMPLEPE O- 16:0;0/22:4;0
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