Non-hydroxy-dihydrosphingosine

We provide MS-based lipid analysis of NdS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of NdS

Structure. Non-hydroxy-fatty acid [N] dihydro-sphingosine [dS] ceramides (CER[NdS], or NdS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Non-hydroxy-dihydrosphingosines are mostly important to human skin where they serve structural and signaling roles. NdS ceramides are involved in the formation of the epidermal barrier to protect against the environment and prevent trans-epidermal water loss. Aberrations of skin ceramide levels can contribute or lead to skin conditions. Reduced levels of NdS ceramides are linked to psoriasis. Further, a fish-rich diet decreases NdS lipids in the liver but elevates them in the brain.

NdS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH, Chol, CE

STRUCTURE
NdS

General molecular structure of non-hydroxy-dihydrosphingosine.

EXAMPLE
NdS 18:0;2/23:0;0

An example for the molecular structure of non-hydroxy-dihydrosphingosine, specifically NdS 18:0;2/23:0;0.

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