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Alpha-hydroxy-phytosphingosine
We provide MS-based lipid analysis of AP ceramides in a variety of sample types and deliver results in as little as three weeks.
About the structure and biological function of AP
Structure. Alpha-hydroxy-fatty acid [A] phytosphingosine [P] ceramides (CER[AP], or AP) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically phytosphingosine, and a fatty acid, which is an α-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.
Function. The function of alpha-hydroxy-phytosphingosines mainly revolves around skin health where they serve structural and signaling roles. AP ceramides contribute to epidermal barrier function which protects against environmental factors and prevents trans-epidermal water loss. They are critical to barrier homeostasis. Skin ceramide profile aberrations can lead or contribute to skin conditions. Further, AP ceramides are increased during winter months in healthy skin and decreased in Albino African skin.
AP lipidomics analysis with
Structural details subspecies level Variants identified > 100 Approach untargeted Method mass spectrometry Device Q Exactive Orbitrap (280.000 Res) Quantification yes Delivery time 3-6 weeks Lipidomics data pmol & mol% Figures included
1 Skin includes:
EXAMPLE STRUCTUREAP
EXAMPLEAP 20:0;3/26:0;1
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