Ceramide

We provide MS-based lipid analysis of Cer sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group
Ceramide
Lipid Class

About the structure and biological function of Cer

Structure. Ceramides (Cer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a long-chain base which is linked to a fatty acid via an amide bond. The long-chain base and the fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Ceramides are essential intermediates in the biosynthesis of all complex sphingolipids. Except for skin, ceramides are rapidly converted and present at trace amounts only, yet they serve important biological roles. They can form ceramide-rich lipid rafts within the cell membrane, and have a vital function in cellular signaling related to apoptosis, cell differentiation, and proliferation. Further, ceramides are linked to metabolic diseases, cancer, neurodegeneration, and cardiovascular disease.

Cer lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Extended includes:
Cer, LPA, LPC, HexCer, LPE, LPG, LPI, LPS, PC O-, PE O-, LPC O-, LPE O-, CL

2Blood Basic includes:
SM, Cer, PI, LPC, TAG, DAG, PC, LPE, PE, PC O-, PE O-, Chol, CE

EXAMPLE STRUCTURE
Cer

An example for the molecular structure of ceramides, specifically Cer 34:0;4.

EXAMPLE
Cer 44:1;2

An example for the molecular structure of ceramides, specifically Cer 44:1;2.

ABOUT LIPOTYPE

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