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Thromboxane
We provide MS-based lipid analysis of TX fatty acyls in a variety of sample types and deliver results in eight or less weeks.
About the structure and biological function of TX
Structure. Thromboxanes (TX) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one six-membered ether-containing ring made of the carbon atoms eight to twelve. All thromboxanes contain at least a hydroxyl group on carbon atom 15 and a double bond at carbon atom 13.
Function. Thromboxanes exert hormone-like functions. They interact with G-protein-linked receptors on the cell surface to activate signal transduction pathways inside the cell. TXs modify inflammatory responses but are most well-known for their role in platelet aggregation, vasoconstriction, and smooth muscle proliferation – they are an essential part of the wound repair mechanism. Thromboxane synthesis and thus platelet aggregation is inhibited by non-steroidal anti-inflammatory drugs like aspirin.
TX lipidomics analysis with
Structural details molecular species Variants identified < 10 Approach targeted Method mass spectrometry Device Agilent 1290 HPLC + 6495 Triplequad Quantification yes Delivery time 6 weeks Lipidomics data pmol & mol% Figures in development
EXAMPLE STRUCTURETX
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