About the structure and biological function of TX
Structure. Thromboxanes (TX) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one six-membered ether-containing ring made of the carbon atoms eight to twelve. All thromboxanes contain at least a hydroxyl group on carbon atom 15 and a double bond at carbon atom 13.
Function. Thromboxanes exert hormone-like functions. They interact with G-protein-linked receptors on the cell surface to activate signal transduction pathways inside the cell. TXs modify inflammatory responses but are most well-known for their role in platelet aggregation, vasoconstriction, and smooth muscle proliferation – they are an essential part of the wound repair mechanism. Thromboxane synthesis and thus platelet aggregation is inhibited by non-steroidal anti-inflammatory drugs like aspirin.
TX lipidomics analysis with
|Structural details||molecular species|
|Variants identified||< 10|
|Device||Agilent 1290 HPLC + 6495 Triplequad|
|Delivery time||6 weeks|
|Lipidomics data||pmol & mol%|
Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.
You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!