Thromboxane

We provide MS-based lipid analysis of TX fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group
Thromboxane
Lipid Class

About the structure and biological function of TX

Structure. Thromboxanes (TX) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one six-membered ether-containing ring made of the carbon atoms eight to twelve. All thromboxanes contain at least a hydroxyl group on carbon atom 15 and a double bond at carbon atom 13.

Function. Thromboxanes exert hormone-like functions. They interact with G-protein-linked receptors on the cell surface to activate signal transduction pathways inside the cell. TXs modify inflammatory responses but are most well-known for their role in platelet aggregation, vasoconstriction, and smooth muscle proliferation – they are an essential part of the wound repair mechanism. Thromboxane synthesis and thus platelet aggregation is inhibited by non-steroidal anti-inflammatory drugs like aspirin.

TX lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
TX

An example for the molecular structure of thromboxane B2.

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