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GD3 Ganglioside

We provide MS-based lipid analysis of GD3 gangliosides in a variety of sample types and deliver results in as little as two weeks.
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Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group
GD3 Ganglioside
Lipid Class

About the structure and biological function of GD3

Structure. GD3 ganglioside lipids belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of four sugar molecules. Two of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. GD3 gangliosides are fundamental in neurogenesis. They bind to the EGF receptor resulting in the activation of a signaling cascade promoting cell proliferation. This is essential for stem cell self-renewal in the brain. GD3 lipids are critical for apoptosis and autophagy, programmed cell death and cellular “self-eating”. They also serve as precursors of more complex gangliosides. Further, GD3 levels are elevated in melanomas and neuroblastomas, and they are the main gangliosides in early human breast milk.

Research articles

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GD3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 25
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Gb3, Gb4, Sulf

EXAMPLE STRUCTURE
GD3

An example for the molecular structure of ganglioside GD3, specifically GD3 34:1;2.

EXAMPLE
GD3 34:1;2

An example for the molecular structure of ganglioside GD3, specifically GD3 34:1;2.

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GD3
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Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Aldehydes Fatty Esters Fatty Amides Heptadecanoids Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA BCFA SCFA MCFA LCFA VLCFA oxiFAL WE CAR NAE oxiHTrE oxiOME oxiODE oxiOTrE Pgd LT TX LX IsoP RvE oxiEDE oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE oxiChol Lano Desm Lath Erg EE C10T C15T Sqe oxiSqe UQ
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