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Squalene

We provide MS-based lipid analysis of Sqe prenol lipids in a variety of sample types and deliver results in six or less weeks.
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Details

Prenol Lipids
Lipid Category
Isoprenoids
Lipid Group
Squalene
Lipid Class

About the structure and biological function of Sqe

Structure. Squalene (Sqe) belongs to the group of isoprenoids within the prenol lipids category. Their structure is based on a linear chain of six five-carbon isoprene units, the building blocks of prenol lipids. Squalene does not encompass further hydrocarbon or oxygen containing substituents.

Function. Squalene serves an important biological function as key precursor to sterol lipids and hopanoids. In most tissues of eukaryotes, squalene is a minor component. Yet Sqe accumulates in sebum, a complex mixture of lipids secreted by the sebaceous glands of mammal skin where it is thought to provide softening effects in the epidermis. Sqe can also break lipid peroxidation by quenching free radicals. Further, squalene is an important component of the vaccine adjuvants AS03 and MF59 which are co-administered with vaccines to stimulate the immune system and increase vaccine efficiency.

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Sqe lipidomics analysis with
Lipotype

Structural detailsclass level
Variants identified 1
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
Sqe

An example for the molecular structure of squalene.

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Sqe
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Categories

Fatty Acyls Glycerolipids Phospholipids Sphingolipids Sterol Lipids Prenol Lipids

Groups

Fatty Acids Fatty Aldehydes Fatty Esters Fatty Amides Heptadecanoids Octadecanoids Eicosanoids Docosanoids Glycerol Esters Ester Phospholipids Ether Phospholipids Diphospha­tidyl­glycerols CDP-Glycerols Sphingoid Bases Ceramide Lipids Cerebrosides Diglycosyl­ceramides Phospho­sphingolipids Gangliosides Globosides Sulfoglyco­sphingolipids Cholesterol Lipids Ergosterol Lipids Isoprenoids Quinones

Classes

FFA BCFA SCFA MCFA LCFA VLCFA oxiFAL WE CAR NAE oxiHTrE oxiOME oxiODE oxiOTrE Pgd LT TX LX IsoP RvE oxiEDE oxiETrE oxiETE oxiEPE MaR RvD PD oxiDPA oxiDHA TAG DAG MAG PA PC PE PG PI PS LPA LPC LPE LPG LPI LPS BMP PC O- PE O- LPC O- LPE O- CL CDP-DAG Sph dhSph SphP dhSphP GlcSph GalSph Cer CerP dhCer doxCer EOdS EOS EOP EOH NdS NS NP NH AdS AS AP AH HexCer GlcCer GalCer DiHexCer LacCer SM CerPE IPC MIPC M(IP)2C GM1 GM2 GM3 GM4 GD1 GD2 GD3 GT1 GT2 GT3 GQ1 Gb3 Gb4 Sulf Chol CE oxiChol Lano Desm Lath Erg EE C10T C15T Sqe oxiSqe UQ
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