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GT3 Ganglioside

We provide MS-based lipid analysis of GT3 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group
GT3 Ganglioside
Lipid Class

About the structure and biological function of GT3

Structure. GT3 ganglioside lipids belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to an oligosaccharide unit made of five sugar molecules. Three of them are sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of GT3 gangliosides in vertebrates but they are elevated in the human retina where they are suggested to play a specific role in the structure and function of the tissue. They also serve as precursors of more complex gangliosides. Modified GT3 gangliosides have been associated with tumors, representing an attractive target for immunotherapeutic approaches using GT3 ganglioside antibodies. Further, GT3 levels are reduced in Alzheimer disease models.

GT3 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Gb3, Gb4, Sulf

EXAMPLE STRUCTURE
GT3

An example for the molecular structure of ganglioside GT3, specifically GT3 36:1;2.

EXAMPLE
GT3 36:1;2

An example for the molecular structure of ganglioside GT3, specifically GT3 36:1;2.

ABOUT LIPOTYPE

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