Deoxyceramide

We provide MS-based lipid analysis of doxCer sphingolipids in a variety of sample types and deliver results in six or less weeks.
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Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group
Deoxyceramide
Lipid Class

About the structure and biological function of doxCer

What is the structure of Deoxyceramide?

Deoxyceramides (deoxyCer, or doxCer) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically deoxysphingosine, and a fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

What is the function of Deoxyceramide?

Deoxyceramides augment the presentation of small glycolipid antigens to T cells and have been linked to therapy-induced senescence, a state of cell cycle arrest in response to chemotherapy. High levels of deoxyCer have also been found in obese patients with type 2 diabetes and dietary interventions have been shown to affect these. Deoxyceramides are suggested to be potential biomarkers insulin sensitivity.

Deoxyceramide lipidomics analysis with Lipotype

Structural details
Variants identified
Approach
Method mass spectrometry
Device
Quantification yes
Delivery time
Lipidomics data pmol & mol%
Figures yes

Example Structure
doxCer

An example for the molecular structure of deoxyceramide, specifically deoxyCer(m18:1;1/16:0;0).

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doxCer
analysis?

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Categories

Fatty AcylsGlycerolipidsPhospholipidsSphingolipidsSterol LipidsPrenol Lipids

Groups

Fatty AcidsFatty AldehydesFatty EstersFatty AmidesHeptadecanoidsOctadecanoidsEicosanoidsDocosanoidsGlycerol EstersEster PhospholipidsEther PhospholipidsDiphospha­tidyl­glycerolsCDP-GlycerolsSphingoid BasesCeramide LipidsCerebrosidesDiglycosyl­ceramidesPhospho­sphingolipidsGangliosidesGlobosidesSulfoglyco­sphingolipidsCholesterol LipidsErgosterol LipidsIsoprenoidsQuinones

Classes

FFABCFASCFAMCFALCFAVLCFAoxiFALWECARNAEoxiHTrEoxiOMEoxiODEoxiOTrEPgdLTTXLXIsoPRvEoxiEDEoxiETrEoxiETEoxiEPEMaRRvDPDoxiDPAoxiDHATAGDAGMAGPAPCPEPGPIPSLPALPCLPELPGLPILPSBMPPC O-PE O-LPC O-LPE O-CLCDP-DAGSphdhSphSphPdhSphPGlcSphGalSphCerCerPdhCerdoxCerEOdSEOSEOPEOHNdSNSNPNHAdSASAPAHHexCerGlcCerGalCerDiHexCerLacCerSMCerPEIPCMIPCM(IP)2CGM1GM2GM3GM4GD1GD2GD3GT1GT2GT3GQ1Gb3Gb4SulfCholCEoxiCholLanoDesmLathErgEEC10TC15TSqeoxiSqeUQ
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