Non-hydroxy-sphingosine

We provide MS-based lipid analysis of NS skin ceramides in a variety of skin sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of NS

Structure. Non-hydroxy-fatty acid [N] sphingosine [S] ceramides (CER[NS], or NS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically sphingosine, and a fatty acid, which is a non-hydroxy fatty acid. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. Non-hydroxy-sphingosines are mainly associated with human skin where they fulfill structural and signaling purposes. NS ceramides contribute to epidermal barrier function to protect against the environment and prevent trans-epidermal water loss. Skin ceramide profile aberrations can lead or contribute to skin conditions. An increase of NS ceramides is associated with psoriasis, a decrease is linked to dry skin. Further, a Nordic diet decreases NS levels in liver but increases brain levels.

NS lipidomics analysis with
Lipotype

Structural detailssubspecies level
Variants identified > 250
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, AdS, AS, AP, AH, NdS, NS, NP, NH, EOdS, EOS, EOP, EOH, Chol, CE

STRUCTURE
NS

General molecular structure of non-hydroxy-sphingosine.

EXAMPLE
NS 18:1;2/30:0;0

An example for the molecular structure of non-hydroxy-sphingosine, specifically NS 18:1;2/30:0;0.

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