Sphingomyelin

We provide MS-based lipid analysis of SM sphingolipids in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Sphingomyelin
Lipid Class

About the structure and biological function of SM

Structure. Sphingomyelins (CerPCho, or SM) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylcholine molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Sphingomyelins play a key role in the cell membrane of animals. They are vital to the formation of lipid rafts and required for the activity of raft-dependent membrane proteins such as some ion channels. They also serve as precursors for sphingolipids in the ‘sphingomyelin cycle’. Further, sphingomyelin metabolism aberrations have been linked to Alzheimer’s and cardiovascular disease.

SM lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 100
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Cells Basic includes:
SM, PG, PI, PS, PA, TAG, DAG, PC, PE, CE

2Blood Basic includes:
SM, Cer, PI, LPC, TAG, DAG, PC, LPE, PE, PC O-, PE O-, Chol, CE

EXAMPLE STRUCTURE
SM

An example for the molecular structure of sphingomyelin, specifically SM 40:3;2.

EXAMPLE
SM 31:1;2

An example for the molecular structure of sphingomyelin, specifically SM 31:1;2.

ABOUT LIPOTYPE

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Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

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