Prostaglandin

We provide MS-based lipid analysis of Pgd fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group
Prostaglandin
Lipid Class

About the structure and biological function of Pgd

Structure. Prostaglandins (Pgd) belong to the group of eicosanoids within the fatty acyls. Their structure consists is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains one five-membered ring made of the carbon atoms eight to twelve. The substituents of the ring define the name of the Pgd species and all prostaglandins contain at least a hydroxyl group on carbon atom 15 and a double bond at carbon atom 13.

Function. Prostaglandins are associated with hormone-like functions. They interact with G-protein-linked receptors on the cell surface to activate cellular signal transduction pathways. Pgds coordinate a multitude of physiological processes, sometimes opposing depending on cell type and stimuli. The best-known function of Pgds in cells is that they modify inflammatory response. Prostaglandin synthesis is inhibited by non-steroidal anti-inflammatory drugs like aspirin to limit their pro-inflammatory effects.

Pgd lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified > 25
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
Pgd

An example for the molecular structure of prostaglandin B2.

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