Oxidized Eicosatrienoic Acid

We provide MS-based lipid analysis of oxiETrE fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Eicosanoids
Lipid Group

About the structure and biological function of oxiETrE

Structure. Oxidized eicosatrienoic acids (oxiETrE) belong to the group of eicosanoids within the fatty acyls. Their structure is based on eicosanoic acid, a twenty carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains three double bonds, from which their name derives. OxiETrE may further encompass multiple hydroxy groups as well as other oxygen containing substituents.

Function. The biological role of oxidized eicosatrienoic acids is mainly associated with blood vessel function. They modulate vascular tone and homeostasis. In vascular inflammation, they impact inflammatory signaling pathways and are also linked to the regulation of blood vessel formation and angiogenesis. However, some oxiETrE lipids act as inhibitors for these biological actions. Further, oxidized eicosatrienoic acids are biosynthetic precursors to some prostaglandin species.

oxiETrE lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified < 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
oxiETrE

An example for the molecular structure of 15-HETrE.

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