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Bis(monoacylglycero)phosphate

We provide MS-based lipid analysis of BMP phospholipids in a variety of sample types and deliver results in six or less weeks.
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Details

Phospholipids
Lipid Category
Ester Phospholipids
Lipid Group
Bis(monoacylglycero)phosphate
Lipid Class

About the structure and biological function of BMP

Structure. Bis-(monoacylglycero)-phosphates (LBPA, or BMP) belong to the group of ester phospholipids within the phospholipids. Their structure consists of two monoacylglycerols linked to each other via a phosphate. In total, BMPs contain two ester-linked fatty acids. They can be of variable length, hydroxylated, and contain double bonds.

Function. Bis-(monoacylglycero)-phosphates play diverse roles in cellular physiology and disease. They are markedly enriched in endosomal and lysosomal vesicles and are involved in membrane docking and digestion, and play a role in lysosomal storage diseases. BMPs are also researched as a non-invasive biomarker to monitor phospholipidosis with drug-induced toxicities. Further, BMPs have been identified as an important actor in the host endocytic machinery hijacked by certain viruses.

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BMP lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified > 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time6 weeks
Lipidomics datapmol & mol%
Figuresincluded

EXAMPLE STRUCTURE
BMP

An example for the molecular structure of bis(monoacylglycero)phosphate, specifically BMP(16:0/18:1(9Z)).

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Categories

Fatty AcylsGlycerolipidsPhospholipidsSphingolipidsSterol LipidsPrenol Lipids

Groups

Fatty AcidsFatty AldehydesFatty EstersFatty AmidesHeptadecanoidsOctadecanoidsEicosanoidsDocosanoidsGlycerol EstersEster PhospholipidsEther PhospholipidsDiphospha­tidyl­glycerolsCDP-GlycerolsSphingoid BasesCeramide LipidsCerebrosidesDiglycosyl­ceramidesPhospho­sphingolipidsGangliosidesGlobosidesSulfoglyco­sphingolipidsCholesterol LipidsErgosterol LipidsIsoprenoidsQuinones

Classes

FFABCFASCFAMCFALCFAVLCFAoxiFALWECARNAEoxiHTrEoxiOMEoxiODEoxiOTrEPgdLTTXLXIsoPRvEoxiEDEoxiETrEoxiETEoxiEPEMaRRvDPDoxiDPAoxiDHATAGDAGMAGPAPCPEPGPIPSLPALPCLPELPGLPILPSBMPPC O-PE O-LPC O-LPE O-CLCDP-DAGSphdhSphSphPdhSphPGlcSphGalSphCerCerPdhCerdoxCerEOdSEOSEOPEOHNdSNSNPNHAdSASAPAHHexCerGlcCerGalCerDiHexCerLacCerSMCerPEIPCMIPCM(IP)2CGM1GM2GM3GM4GD1GD2GD3GT1GT2GT3GQ1Gb3Gb4SulfCholCEoxiCholLanoDesmLathErgEEC10TC15TSqeoxiSqeUQ
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