Omega-hydroxy-dihydrosphingosine

We provide MS-based lipid analysis of EOdS ceramides in a variety of sample types and deliver results in as little as three weeks.

Details

Sphingolipids
Lipid Category
Ceramide Lipids
Lipid Group

About the structure and biological function of EOdS

Structure. Omega-hydroxy-fatty acid [EO] dihydro-sphingosine [dS] ceramides (CER[EOdS], or EOdS) belong to the group of ceramide lipids within the sphingolipids. Their structure consists of a sphingoid base, specifically dihydrosphingosine, and a fatty acid. The fatty acid is an ω-hydroxy fatty acid and “elongated” by a further fatty acid via an ester bond. The fatty acid can be of variable length, hydroxylated, and contain double bonds.

Function. The biological function of omega-hydroxy-dihydrosphingosines mostly revolves around skin health where they serve mainly structural roles. EOdS ceramides are critical to the formation of the lamellar phase of the epidermal barrier which prevents trans-epidermal water loss but also protects from the environment. Imbalanced skin ceramides can contribute or lead to the development of skin conditions. In general, reduced levels of omega-hydroxy ceramides are linked to dry skin and psoriasis.

EOdS lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 10
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time3-6 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Skin includes:
TAG, DAG, EOdS, EOS, EOP, EOH, NdS, NS, NP, NH, AdS, AS, AP, AH, Chol, CE

EXAMPLE STRUCTURE
EOdS

An example for the molecular structure of omega-hydroxy-dihydrosphingosines, specifically EOdS 70:2;2.

EXAMPLE
EOdS 66:2;2

An example for the molecular structure of omega-hydroxy-dihydrosphingosines, specifically EOdS 66:2;2.

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