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Gb3 Globoside

We provide MS-based lipid analysis of Gb3 globosides in a variety of sample types and deliver results in as little as two weeks.


Lipid Category
Lipid Group
Gb3 Globoside
Lipid Class

About the structure and biological function of Gb3

Structure. Gb3 globoside lipids (globo-triaosylceramides, ceramide trihexosides, or antigen CD77) belong to the group of globosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a neutral oligosaccharide unit made of three sugar molecules. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Gb3 globosides specifically interact with the cellular “death receptor” FasR. When paired to a Gb3, FasR transduces a cell death signal derived from activation of the caspase-8 cascade. A genetic defect in the enzyme alpha-galactosidase leads to accumulation of Gb3, causing Fabry’s disease, a lysosomal storage disease. Further, Gb3 are a component of the cell membrane where they bind to Shigatoxins facilitating their entry into cells.

Gb3 lipidomics analysis with

Structural detailsspecies level
Variants identified > 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Delivery time2-4 weeks
Lipidomics datapmol & mol%
1Glycosphingolipids includes:
DiHexCer, GM1, GM2, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1, Gb3, Gb4, Sulf


An example for the molecular structure of globoside Gb3, specifically Gb3 36:1;2.

Gb3 32:1;2

An example for the molecular structure of globoside Gb3, specifically Gb3 32:1;2.


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