GM4 Ganglioside

We provide MS-based lipid analysis of GM4 gangliosides in a variety of sample types and deliver results in as little as two weeks.

Details

Sphingolipids
Lipid Category
Gangliosides
Lipid Group
GM4 Ganglioside
Lipid Class

About the structure and biological function of GM4

Structure. GM4 ganglioside lipids belong to the group of gangliosides within the sphingolipids. Their structure consists of a ceramide backbone linked to a disaccharide unit. One of them is a sialic acid. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Little is known about the function of GM4 gangliosides in vertebrates but they have been found to be a major ganglioside within myelin, the insulating layer that is produced by oligodendrocytes and forms around the axons of neurons. GM4 lipids are increased in the frontal cortex of Alzheimer’s patients. Further, GM4 supports oligodendrocyte proliferation, a process that is important for remyelination of demyelinated neurons and is impaired in multiple sclerosis.

GM4 lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified < 10
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Glycosphingolipids includes:
DiHexCer, Gb3, Gb4, GM1, GM2, Sulf, GM3, GM4, GD1, GD2, GD3, GT1, GT2, GT3, GQ1

STRUCTURE
GM4

General molecular structure of the ganglioside GM4.

EXAMPLE
GM4 36:1;2

An example for the molecular structure of ganglioside GM4, specifically GM4 36:1;2.

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