Home   Lipotype Lipidomics   Sphingolipids   Phosphosphingolipids   IPC 

Inositol­phosphoryl-ceramide

We provide MS-based lipid analysis of IPC phosphosphingolipids in yeast samples and deliver results in as little as two weeks.

About the structure and biological function of IPC

Structure. Inositolphosphoryl-ceramides (inositol-P-ceramides, or IPC) belong to the group of phosphosphingolipids within the sphingolipids. Their structure consists of a ceramide backbone bound to a phosphorylinositol molecule. The ceramide backbone contains two hydrocarbon chains: a long-chain base which is linked to a fatty acid via an amide bond. The fatty acid and the long-chain base can be of variable length, hydroxylated, and contain double bonds.

Function. Inositolphosphoryl-ceramides are substantial components of biological membranes in yeast. In lipid rafts of the cell membrane, IPC lipids interact with membrane proteins with signaling functions – a role similar to those of sphingomyelins in animals. IPC ceramides are also the precursor for further complex glycophosphosphingolipids. Further, the biosynthesis of IPC lipids reduces the pool of intracellular ceramide and thus inhibits programmed cell death.

IPC lipidomics analysis with
Lipotype

Structural detailsspecies level
Variants identified > 50
Approachuntargeted
Methodmass spectrometry
DeviceQ Exactive Orbitrap (280.000 Res)
Quantificationyes
Delivery time2-4 weeks
Lipidomics datapmol & mol%
Figuresincluded
1Yeast includes:
CDP-DAG, IPC, MIPC, M(IP)2C, Erg, EE

EXAMPLE STRUCTURE
IPC

An example for the molecular structure of inositolphosphoryl-ceramide, specifically IPC 46:0;4.

EXAMPLE
IPC 40:0;3

An example for the molecular structure of inositolphosphoryl-ceramide, specifically IPC 40:0;3.

ABOUT LIPOTYPE

Lipotype is the leading lipidomics service provider for industry and academia. Order your service, send your samples, get your data.

  • Thank you once again. The timing is extremely helpful to us.

    Susan Macdonald

    Aldeyra Therapeutics
  • Thank you very much. The results look fantastic!

    Stan Neufeld

    Friedrich Miescher Institute
  • The high-speed turn around when under revision really helped us!

    Rose E Goodchild

    KU Leuven
  • We highly appreciate the personal support and consultation.

    Rainer Voegeli

    DSM Skin Biology
  • We have been quite impressed. The results clearly indicate a difference.

    Pietro De Camilli

    Yale University
  • Cooperating with Lipotype, I enjoy custom packages and great support!

    Olga Ramich

    DIfE
  • After moving from one continent to another, I still prefer Lipotype!

    Julie Jacquemyn

    University of Alberta
  • Thank you very much for my new and shiny lipidomics data set!

    Ilya Levental

    University of Virginia
  • Lipotype Lipidomics is instrumental to our studies of membranes.

    Christopher J Stefan

    University College London
  • Lipotype is truly dedicated to supporting scientists in their research.

    Anonymous

    Anonymous

Request Analysis

You want to inquire lipid analysis for your project or ask questions about Lipotype Lipidomics? Please use the contact form below!