Oxidized Docosa­hexaenoic Acid

We provide MS-based lipid analysis of oxiDHA fatty acyls in a variety of sample types and deliver results in eight or less weeks.

Details

Fatty Acyls
Lipid Category
Docosanoids
Lipid Group

About the structure and biological function of oxiDHA

Structure. Oxidized docosahexaenoic acids (oxiDHA) belong to the group of docosanoids within the fatty acyls. Their structure is based on docosanoic acid, a twenty-two carbon atoms long hydrocarbon chain with a carboxyl group. The chain contains six double bonds, from which their name derives. Further, oxiDHAs may further encompass multiple hydroxy groups as well as other oxygen containing substituents.

Function. The biological function of oxidized docosahexaenoic acids is mainly associated with modifying inflammatory responses through interacting with G-protein-linked receptors on the cell surface. They are also believed to impact cognitive and behavioral function in human infants. Further, oxidized docosahexaenoic acids are biosynthetic intermediates to a variety of other docosanoid lipids, and oxiDHA lipids may be responsible for some of the beneficial effects linked to dietary omega-3 fatty acids.

oxiDHA lipidomics analysis with
Lipotype

Structural detailsmolecular species
Variants identified > 10
Approachtargeted
Methodmass spectrometry
DeviceAgilent 1290 HPLC + 6495 Triplequad
Quantificationyes
Delivery time8 weeks
Lipidomics datapmol & mol%
Figuresin development

EXAMPLE STRUCTURE
oxiDHA

An example for the molecular structure of 17-HDHA.

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